On Season 5's first episode, Ruff is caught up trying to locate his long-lost parents, and forgets to choose his Season 5 contestants. When he does, he loses them on their way to Studio G. He also learns that a competitor show, Go Get It, has come on the market which is actually a rip-off of Fetch.

Ruff finds his lost FETCHers on a mysterious island, known as Game Show Island. In order for them to leave the island, they must find relics from "The Fabulous Four" gameshow by sundown. Meanwhile, Ruff finds clues on where his parents are.

Ruff finds out that his cousin, Bluff Ruffman is sending animals to the doghouse. Ruff sends Shreya and Marco to Disneyworld in Florida to learn how to care for animals. Meanwhile, Rubye is sent to Las Vegas to learn magic tricks from Penn and Teller. Jay, Emmie, and Marc stay behind.

Ruff learns from Crush, a turtle in Finding Nemo that there is trouble going on with the turtles. So Ruff sends Marco and Shreya go to Florida to learn about turtles and help with the turtle hatchlings on the beach. Meanwhile, Jay appears on a radio game show. Marc, Emmie and Rubye stay behind.

Ruff inherits Ruffman Manor, but finds out it is haunted. Ruff receives an invitation to go to Ruffman Manor, but instead sends out all the kids to spend the night to see if it is truly haunted.

Chet signs Ruff up for a boxing match versus Whipped Cream McGee. Ruff sends out Shreya to learn how to box, and sends out Marc and Marco to meet a helmet designer to design a boxing helmet for Ruff. Rubye, Emmie and Jay stay behind.

Ruff wants to send a letter to his parents. So Ruff sends Emmie out to make her own cheese and sends out Rubye and Jay to meet a carrier pigeon. Marc, Marco, and Shreya stay behind.

Ruff sends Rubye and Jay to engineer a bear-proof picnic basket. Shreya, Emmie, Marc, Marco compete in a wedding cake bake-off. No Fetcher stays behind.

Emmie and Marco analyze fossilized dinosaur footprints out in the field, while Rubye and Shreya learn how to make a good trade. Marc, & Jay stayed behind.

Emmie and Shreya learn how to build a hovercraft and then compete in a fetching race. Ruff sends Jay and Marco to invent a device that will make his life easier. Marc & Rubye stayed behind.

Ruff sends Emmie and Marc to learn how to mime. Then he sends Jay and Rubye to learn how to build sculptures that move. Marco & Shreya stayed behind.

Ruff believes a sarcophagus he found in his backyard contains a cursed Egyptian mummy, so he sends the kids to a museum to carbon date the mummy to prove his hunch. Along the way, the kids enjoy an Egypt-theme amusement park.

Ruff wants to make a recent dream ---in which he was flying with an elephant---come true.So he sends Marco to an elephant sanctuary to learn how to care for elephants, and has Marc and Rubye learn to skydive indoors.

Ruff's rock-star cousin Rüf Rüfman wants songbirds on his next album, so Ruff sends Emmie and Rubye to the field to work with songbirds. Ruff also sends Marc and Shreya to learn how to dance with their hands.

To prepare for a family-reunion barbecue that will include distant wolf relatives, Ruff sends Emmie and Rubye to Yellowstone National Park to learn about wolves, and Ruff sends Jay and Marc to South Carolina to learn about Southern barbecue.

FETCH! competes with Go Get It!, the rival cat game show, in a synchronized swimming match, so he sends Marco, Shreya, and Rubye to learn about synchronized swimming, and he sends Marc to Mystic Aquarium to learn how beluga whales are adapted for the water.

FETCH!'s rival game show Go Get It! is produced by a mysterious organization called PURRS. Ruff sends all six kids to meet with a team of private investigators and learn how to become gumshoes. Ruff and the FETCHers then try to use their sleuthing skills to get to the bottom of who is behind PURRS.

Ruff's nephew Glen has been playing a pirate-themed video game on the Go Get It! website. Through this game he's somehow gotten into the Go Get It! mainframe computer, and discovers that they're hunting for something called The Golden Fetchie. Ruff wants to find the FETCHie first, so he sends the kids off to the island. And at Glen's request, he makes them dress up as pirates.

Ruff has learned that PURRS, the organization that runs Go Get It!, is an evil cat organization! PURRS plans to brainwash the entire country with a device that makes everyone think they're cats. PURRS is also responsible for the disappearance of Ruff's parents. After learning that PURRS headquarters is hidden somewhere inside a water park, Ruff sends the FETCHers to find a way inside. The HQ of PURRS is Studio P, Go Get It's Studio (Only a remodeled Studio G in production terms). The season finale was incorporated during the whole episode and the final winner of the show is determined.