As Barry Allen stands on the threshold of his impending death in Crisis, his convictions are tested when the monstrous Dr. Ramsey Rosso infects The Flash with a mysterious, hallucinogenic contagion. Meanwhile, reporter Iris West-Allen uncovers a vast conspiracy.

Barry and Iris come together to try and stop a dangerous force from destroying Central City.

Barry is shocked when Eobard Thawne returns in the most unexpected way, and with a tie to a loved one. Damien Darhk offers advice to Barry but there is a catch. An epic battle begins with Reverse Flash pitted against The Flash, Team Flash, Batwoman, Sentinel and Ryan Choi.

As Barry and Iris prepare for their new life, luck changes for those in Central City. Cecile takes on a case with Allegra's help, involving a string of unfortunate – and highly unexpected – events. Meanwhile, Chester and the team work with Khione to figure out her abilities.