Cindy Peterson, a mother who had become a stripper to support her family, goes missing after work one night, and Jack sends Elena in undercover at the strip club to learn what she can. Danny moves in to keep an eye on her after someone catches on to her spying, while Vivian discovers that Jim Peterson hasn't been completely honest with them. Jack faces censure from Olczyk over his relationship with Ann, and is angry with Ann after she admits to him that she thinks he let their relationship cloud his judgment in the Davis investigation.

When 17-year-old Ted Soros goes missing after a basketball game, the team begins an investigation, soon learning that Ted was an emancipated minor who was living on his own to attend a school with an exemplary basketball program. Learning he had recently contacted his mother with a request for legal advice from an uncle, the team begins to suspect that Ted may have done something that he could face criminal charges for, and realise that Ted's secret is connected to a university recruiting party. While the team works Ted's disappearance, Jack learns from Ann that she lost the baby, and waits for her at the clinic while she seeks medical attention.

Sam's darkest secrets are revealed when her sister goes missing she decides to search for her without the team's help.

Malone's team joins forces with Gil Grissom, a CSI from Las Vegas, and his team as they track a serial killer with ties to New York.

The crossover starts on CSI: Crime Scene Investigation S08E06 Who and What (I).

While struggling to deal with the aftermath of Jack's accident, the team searches to find a teen heart transplant recipient, believing her disappearance might be connected to her donor. Samantha talks to Brian.

Five people with an odd connection go missing from a coffee shop, and the team determines what the connection had to do with their disappearance. Meanwhile, Samantha gets ready for the birth of her child.

The team must shift their attention from a case they are working on and hand it over to Martin, after a child is reported to have been kidnapped at a mall.

While working on a high profile civil case, a trial consultant vanishes. Jack and Sam learn how to make adjustments as Brian and Finn spend more time together.

The team looks for a missing journalist after her hardcore exposes are published on an on-line magazine. They begin to suspect a politician, the subject of one of her latest entries. Meanwhile, Brian remains in Sam and Finn's life.