Louis de Pointe du Lac lives in 1910 New Orleans as executor-in-charge of his family's fortune. When he meets the vampire Lestat, Louis' life begins to unravel in otherworldly ways. 110 years later, Louis tells his story to journalist Daniel Molloy.

Beginning his life as a vampire, Louis learns the rules of vampirism from his maker and companion Lestat. Louis discovers increasing differences between himself and Lestat. In Dubai, Louis reveals more of his modern day vampire lifestyle to Molloy.

Louis continues his life as a businessman of Storyville. When an old friend comes to town, Louis's relationship with Lestat is tested. Louis' business intertwines with growing tensions in New Orleans, leading to a new chapter in Louis' vampire life.